Treatment Marble Bone Disease

Complications of paget s disease of bone can include broken bones hearing loss and pinched nerves in your spine.

Treatment marble bone disease.

Bone marrow transplant and splenectomy may be useful in some patients. This treatment resulted in improvement of growth retardation. This allows the restoration of bone resorption by donor derived osteoclasts. What are treatments for osteopetrosis or marble bone disease.

Bone marrow transplant has many risks but if it is successful it saves the life of a child who would otherwise die from complications of the disorder. Corti costeroids high dose calcitriol have been helpful in the treatment of osteopetrosis. Bisphosphonates the medications also used to strengthen bones weakened by osteoporosis are the mainstay of treatment. Osteopetrosis can cause bones to dissolv.

Bone marrow transplant is the only complete cure available for malignant marble bone disease. For patients who have complications surgery may be necessary. Advertisement in cases of osteopetrosis in adults there are no treatments required. Osteopetrosis literally stone bone also known as marble bone disease or albers schönberg disease is an extremely rare inherited disorder whereby the bones harden becoming denser in contrast to more prevalent conditions like osteoporosis in which the bones become less dense and more brittle or osteomalacia in which the bones soften.

Optimal transplants require donor marrow from a sibling. Treatment strategies include correcting anemia thrombocytopenia and treating infections. Bone marrow transplantation bmt markedly improves some cases of severe infantile osteopetrosis associated with bone marrow failure and offers the best chance of longer term survival for individuals with this type. At present the only established cure for autosomal recessive malignant infantile osteopetrosis is hematopoietic stem cell transplantation hsct for specific cases.

In pediatric childhood osteopetrosis surgery is sometimes needed because of fractures.